Pharmaceutical Seamless Capsules

Nearly Perfect Sphere and “Seamless” Capsule Formulation
Flexibility in Setting Capsule Size, Dissolution Time and Coating

Seamless capsules are manufactured using the property of liquids to form spherical shapes that occur due to surface tension. Capsule sizes can be customized from as small as 1 mm to about 10 mm. Thickness and hardness of the coating can also be adjusted.

Solutions Provided by Sunsho Pharmaceutical Softgel Capsules

  • ・Enhances absorption (bioavailability) of insoluble drugs.
  • ・Achieves formulation uniformity even for active ingredients of 1 mg or less.
  • ・Accelerates product development with a simpler manufacturing process and easier validation.
  • ・End-to-end support from clinical trial drug manufacturing to commercial production.

Characteristics, Advantages

  • Characteristics, Advantages

    Selectable Size

    Capsule size can be adjusted flexibly from approximately 1 mm to 10 mm.
  • Selectable Dissolution Time

    Selectable Dissolution Time

    Dissolution time within the body can be adjusted from a few seconds to a few hours.
  • Selectable Thickness and Hardness

    Selectable Thickness and Hardness

    Thickness of the shell can be customized from a few μm to several mm.

Seamless Capsule Shapes

  • Cross Section of a Seamless Capsule
  • A. Shell

    • ・Gelatin shell
    • ・Thickness ranges from several μm to several millimeters

    B. Filling Ingredient

    • ・Oils (liquid plant oils, animal fats, fragrances, etc. at room temperature)
    • ・Oil-soluble powder

Manufacturing Process

  • Manufacturing Method of Seamless Capsules ●Filling ingredient flows from the inner nozzle of the double nozzle, while the coating liquid for the shell flows from the outer nozzle, both at a constant rate.  This method involves cutting the two layers of liquid at regular intervals, forming droplets through interfacial tension, and then gelling the outer membrane for encapsulation. ●Molding ProcessManufacturing Method of Seamless Capsules ●Filling ingredient flows from the inner nozzle of the double nozzle, while the coating liquid for the shell flows from the outer nozzle, both at a constant rate.  This method involves cutting the two layers of liquid at regular intervals, forming droplets through interfacial tension, and then gelling the outer membrane for encapsulation. ●Molding Process